Version 5.4
Homo sapiens Gene: ACAD8
Summary
InnateDB Gene IDBG-76517.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAD8
Gene Name acyl-CoA dehydrogenase family, member 8
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151498
Encoded Proteins
IDBP-76519
acyl-CoA dehydrogenase family, member 8
IDBP-76523
acyl-CoA dehydrogenase family, member 8
IDBP-594365
acyl-CoA dehydrogenase family, member 8
IDBP-587221
acyl-CoA dehydrogenase family, member 8
IDBP-591951
acyl-CoA dehydrogenase family, member 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. The encoded protein is a mitochondrial enzyme that functions in catabolism of the branched-chain amino acid valine. Defects in this gene are the cause of isobutyryl-CoA dehydrogenase deficiency.[provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:134253495-134265855
Strand Forward strand
Band q25
Transcripts
ENST00000281182 ENSP00000281182
ENST00000374752 ENSP00000363884
ENST00000526026 ENSP00000431532
ENST00000524426 ENSP00000431310
ENST00000534433
ENST00000525961
ENST00000530533
ENST00000534240
ENST00000533387
ENST00000527082
ENST00000524547
ENST00000531338
ENST00000528325
ENST00000527665
ENST00000527713
ENST00000524739
ENST00000524502 ENSP00000434193
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003995 acyl-CoA dehydrogenase activity
GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors
GO:0050660 flavin adenine dinucleotide binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006574 valine catabolic process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031969
View Gene Order
ENSBTAG00000012937
Not yet available
Pathways
NETPATH
REACTOME
REACT_197
Branched-chain amino acid catabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00280
Valine, leucine and isoleucine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.14791 Hs.608066
RefSeq NM_014384 XM_005271501
HUGO
OMIM
CCDS CCDS8498
HPRD 11985
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca