Version 5.4
Homo sapiens Gene: ITGA4
Summary
InnateDB Gene IDBG-76684.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGA4
Gene Name integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Synonyms CD49D; IA4
Species Homo sapiens
Ensembl Gene ENSG00000115232
Encoded Proteins
IDBP-76686
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
IDBP-76688
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
IDBP-236253
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
IDBP-807309
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:181457202-181536187
Strand Forward strand
Band q31.3
Transcripts
ENST00000233573 ENSP00000233573
ENST00000339307 ENSP00000340149
ENST00000397033 ENSP00000380227
ENST00000476089
ENST00000465522
ENST00000484404
ENST00000478440
ENST00000473002
ENST00000490435
ENST00000476824
ENST00000468948
ENST00000614742 ENSP00000480701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 499 experimentally validated interaction(s) in this database.
Experimentally validated
Total 499 [view]
Protein-Protein 498 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0050839 cell adhesion molecule binding
Biological Process
GO:0001974 blood vessel remodeling
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0016477 cell migration
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
GO:0060324 face development
GO:0060710 chorio-allantoic fusion
GO:0072678 T cell migration
GO:0090074 negative regulation of protein homodimerization activity
Cellular Component
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0008305 integrin complex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027009
View Gene Order
ENSBTAG00000009256
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04640
Hematopoietic cell lineage pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04512
ECM-receptor interaction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC) pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
hsa05414
Dilated cardiomyopathy pathway
hsa04672
Intestinal immune network for IgA production pathway
hsa05140
Leishmaniasis pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin1_pathway
Beta1 integrin cell surface interactions
integrin_cs_pathway
Integrin family cell surface interactions
lymphangiogenesis_pathway
VEGFR3 signaling in lymphatic endothelium
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
a4b7_pathway
a4b7 Integrin signaling
integrin5_pathway
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL A0A023IP86 A0A023IP88 A0A023IP90 A0A023IPA8 A0A023IPA9 A0A023IPH2 A0A023IPI3 A0A023IQJ3 A0A023IQJ5 A0A023IQK0 Q8IUA2
UniProt Splice Variant
Entrez Gene 3676
UniGene
RefSeq NM_000885
HUGO HGNC:6140
OMIM 192975
CCDS CCDS42788
HPRD
IMGT
EMBL AJ510246 AJ510247 KF671586 KF671587 KF671588 KF671589 KF671590 KF671591 KF671592 KF671593 KF671594 KF671595 KF671596 KF671597 KF671598 KF671599 KF671600 KF671601 KF671602 KF671603 KF671604 KF671605 KF671606 KF671607 KF671608 KF671609 KF671610 KF671611 KF671612 KF671613 KF671614 KF671615 KF671616 KF671617 KF671618 KF671619 KF671620 KF671621 KF671622 KF671623 KF671624 KF671625 KF671626 KF671627 KF671628 KF671629 KF671630 KF671631 KF671632 KF671633 KF671634 KF671635 KF671636 KF671637 KF671638 KF671639 KF671640 KF671641 KF671642 KF671643 KF671644 KF671645 KF671646 KF671647 KF671648 KF671649 KF671650 KF671651 KF671652 KF671653 KF671654 KF671655 KF671656 KF671657 KF671658 KF671659 KF671660 KF671661 KF671662 KF671663 KF671664 KF671665 KF671666 KF671667 KF671668 KF671669 KF671670 KF671742 KF671743 KF671744 KF671745 KF671746 KF671747 KF671748 KF671749 KF671750 KF671751 KF671753 KF671754 KF671755 KF671756
GenPept AGZ05039 AGZ05040 AGZ05041 AGZ05042 AGZ05043 AGZ05044 AGZ05045 AGZ05046 AGZ05047 AGZ05048 AGZ05049 AGZ05050 AGZ05051 AGZ05052 AGZ05053 AGZ05054 AGZ05055 AGZ05056 AGZ05057 AGZ05058 AGZ05059 AGZ05060 AGZ05061 AGZ05062 AGZ05063 AGZ05064 AGZ05065 AGZ05066 AGZ05067 AGZ05068 AGZ05069 AGZ05070 AGZ05071 AGZ05072 AGZ05073 AGZ05074 AGZ05075 AGZ05076 AGZ05077 AGZ05078 AGZ05079 AGZ05080 AGZ05081 AGZ05082 AGZ05083 AGZ05084 AGZ05085 AGZ05086 AGZ05087 AGZ05088 AGZ05089 AGZ05090 AGZ05091 AGZ05092 AGZ05093 AGZ05094 AGZ05095 AGZ05096 AGZ05097 AGZ05098 AGZ05099 AGZ05100 AGZ05101 AGZ05102 AGZ05103 AGZ05104 AGZ05105 AGZ05106 AGZ05107 AGZ05108 AGZ05109 AGZ05110 AGZ05111 AGZ05112 AGZ05113 AGZ05114 AGZ05115 AGZ05116 AGZ05117 AGZ05118 AGZ05119 AGZ05120 AGZ05121 AGZ05122 AGZ05123 AGZ05195 AGZ05196 AGZ05197 AGZ05198 AGZ05199 AGZ05200 AGZ05201 AGZ05202 AGZ05203 AGZ05204 AGZ05205 AGZ05206 AGZ05207 AGZ05208 AGZ05210 AGZ05211 AGZ05212 AGZ05214 AGZ05215 CAD53326 CAD53327
RNA Seq Atlas 3676

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca