Version 5.4
Homo sapiens Gene: YWHAB
Summary
InnateDB Gene IDBG-76944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YWHAB
Gene Name tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Synonyms GW128; HEL-S-1; HS1; KCIP-1; YWHAA
Species Homo sapiens
Ensembl Gene ENSG00000166913
Encoded Proteins
IDBP-76946
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
IDBP-76948
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
IDBP-376081
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
IDBP-376082
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:44885676-44908532
Strand Forward strand
Band q13.12
Transcripts
ENST00000353703 ENSP00000300161
ENST00000372839 ENSP00000361930
ENST00000428262 ENSP00000394729
ENST00000445830 ENSP00000394558
ENST00000479421
ENST00000477896
ENST00000479758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 442 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 442 [view]
Protein-Protein 439 [view]
Protein-DNA 1 [view]
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
GO:0019904 protein domain specific binding
GO:0032403 protein complex binding
GO:0042826 histone deacetylase binding
GO:0050815 phosphoserine binding
GO:0051219 phosphoprotein binding
Biological Process
GO:0000165 MAPK cascade
GO:0000186 activation of MAPKK activity
GO:0006605 protein targeting
GO:0006915 apoptotic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007265 Ras protein signal transduction
GO:0007411 axon guidance
GO:0008286 insulin receptor signaling pathway
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0035308 negative regulation of protein dephosphorylation
GO:0035329 hippo signaling
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0043085 positive regulation of catalytic activity
GO:0045087 innate immune response
GO:0045892 negative regulation of transcription, DNA-templated
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051220 cytoplasmic sequestering of protein
GO:0051291 protein heterooligomerization
GO:0061024 membrane organization
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0017053 transcriptional repressor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0042470 melanosome
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018326
View Gene Order
ENSBTAG00000016846
Not yet available
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
NetPath_9
TNFalpha pathway
NetPath_15
IL3 pathway
REACTOME
REACT_2077
RAF activation pathway
REACT_614
RAF phosphorylates MEK pathway
REACT_962
MEK activation pathway
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_23898
Rap1 signalling pathway
REACT_27283
Interleukin-2 signaling pathway
REACT_12076
Frs2-mediated activation pathway
REACT_12002
ARMS-mediated activation pathway
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_12033
Signalling to RAS pathway
REACT_524
SOS-mediated signalling pathway
REACT_12579
SHC1 events in EGFR signaling pathway
REACT_12606
GRB2 events in EGFR signaling pathway
REACT_9417
Signaling by EGFR pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_116005
SHC1 events in ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_661
SHC-mediated signalling pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150139
SHC-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_115854
GRB2 events in ERBB2 signaling pathway
REACT_115993
SHC1 events in ERBB2 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_21247
FRS2-mediated cascade pathway
REACT_9470
Signaling by FGFR pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_118607
Signaling by Hippo pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_549
Activation of BAD and translocation to mitochondria pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_999
SHC-related events pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_21272
Downstream signaling of activated FGFR pathway
REACT_12529
Signaling by VEGF pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_634
RAF/MAP kinase cascade pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_75774
Adaptive Immune System pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_6900
Immune System pathway
REACT_228024
VEGFR2 mediated cell proliferation pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_22232
Signaling by Interleukins pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_12005
Prolonged ERK activation events pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04110
Cell cycle pathway
hsa04114
Oocyte meiosis pathway
INOH
INOH website
Wnt signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
Fas signaling pathway pathway
PID NCI
hdac_classii_pathway
Signaling events mediated by HDAC Class II
atm_pathway
ATM pathway
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.643544 Hs.713768
RefSeq NM_003404 NM_139323
HUGO
OMIM
CCDS CCDS13339
HPRD 03184
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca