Version 5.4
Homo sapiens Gene: TFPI
Summary
InnateDB Gene IDBG-77150.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFPI
Gene Name tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Synonyms EPI; LACI; TFI; TFPI1
Species Homo sapiens
Ensembl Gene ENSG00000003436
Encoded Proteins
IDBP-77152
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-77154
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-245803
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-293330
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387934
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387935
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387936
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387937
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387938
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387939
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
IDBP-387940
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:187464230-187565760
Strand Reverse strand
Band q32.1
Transcripts
ENST00000233156 ENSP00000233156
ENST00000339091 ENSP00000342306
ENST00000392365 ENSP00000376172
ENST00000409676 ENSP00000386344
ENST00000426055 ENSP00000397248
ENST00000435414 ENSP00000409177
ENST00000421427 ENSP00000408170
ENST00000437725 ENSP00000388159
ENST00000453013 ENSP00000394185
ENST00000417013 ENSP00000400179
ENST00000420747 ENSP00000402954
ENST00000481132
ENST00000481389
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0007596 blood coagulation
GO:0007598 blood coagulation, extrinsic pathway
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0031090 organelle membrane
GO:0031225 anchored component of membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000027082
View Gene Order
Pathways
NETPATH
REACTOME
REACT_1573
Extrinsic Pathway pathway
REACT_2051
Formation of Fibrin Clot (Clotting Cascade) pathway
REACT_604
Hemostasis pathway
KEGG
hsa04610
Complement and coagulation cascades pathway
INOH
PID NCI
syndecan_4_pathway
Syndecan-4-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.516578 Hs.619450
RefSeq NM_001032281 NM_006287 XM_005246818 XM_005246819 XM_005246820 XM_006712720
HUGO
OMIM
CCDS CCDS2294 CCDS33349
HPRD 01064
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca