Version 5.4
Homo sapiens Gene: HSD17B3
Summary
InnateDB Gene IDBG-77323.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B3
Gene Name hydroxysteroid (17-beta) dehydrogenase 3
Synonyms EDH17B3; SDR12C2
Species Homo sapiens
Ensembl Gene ENSG00000130948
Encoded Proteins
IDBP-77325
hydroxysteroid (17-beta) dehydrogenase 3
IDBP-77327
hydroxysteroid (17-beta) dehydrogenase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:96235306-96302152
Strand Reverse strand
Band q22.32
Transcripts
ENST00000375263 ENSP00000364412
ENST00000375262 ENSP00000364411
ENST00000464104
ENST00000494814
ENST00000467499
ENST00000484816
ENST00000463517
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016491 oxidoreductase activity
GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity
Biological Process
GO:0006702 androgen biosynthetic process
GO:0008152 metabolic process
GO:0008202 steroid metabolic process
GO:0030539 male genitalia development
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0061370 testosterone biosynthetic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033122
View Gene Order
ENSBTAG00000016867
Not yet available
Pathways
NETPATH
REACTOME
REACT_11059
Androgen biosynthesis pathway
REACT_380
Synthesis of very long-chain fatty acyl-CoAs pathway
REACT_1319
Fatty Acyl-CoA Biosynthesis pathway
REACT_1190
Triglyceride Biosynthesis pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_11057
Metabolism of steroid hormones and vitamin D pathway
REACT_111217
Metabolism pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.477
RefSeq NM_000197
HUGO
OMIM
CCDS CCDS6716
HPRD 05716
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca