Version 5.4
Homo sapiens Gene: MSTN
Summary
InnateDB Gene IDBG-77438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MSTN
Gene Name myostatin
Synonyms GDF8; MSLHP
Species Homo sapiens
Ensembl Gene ENSG00000138379
Encoded Proteins
IDBP-77440
myostatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. This gene is thought to encode a secreted protein which negatively regulates skeletal muscle growth. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:190055697-190062729
Strand Reverse strand
Band q32.2
Transcripts
ENST00000260950 ENSP00000260950
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0042802 identical protein binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007517 muscle organ development
GO:0009408 response to heat
GO:0009629 response to gravity
GO:0014732 skeletal muscle atrophy
GO:0014741 negative regulation of muscle hypertrophy
GO:0014850 response to muscle activity
GO:0022602 ovulation cycle process
GO:0033574 response to testosterone
GO:0040007 growth
GO:0043403 skeletal muscle tissue regeneration
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048632 negative regulation of skeletal muscle tissue growth
GO:0051384 response to glucocorticoid
GO:0051602 response to electrical stimulus
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026100
View Gene Order
ENSBTAG00000011808
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt O14793
TrEMBL Q53S46
UniProt Splice Variant
Entrez Gene 2660
UniGene Hs.41565
RefSeq NM_005259
HUGO HGNC:4223
OMIM 601788
CCDS CCDS2303
HPRD 03474
IMGT
EMBL AC073120 AF019627 AF104922 AK291524 BC074757 CH471058 DQ927048 DQ927050 DQ927053 DQ927055 DQ927057 DQ927058 DQ927059 DQ927061 DQ927064 DQ927065 DQ927068 DQ927069 DQ927070 DQ927072 DQ927080 DQ927081 DQ927083 DQ927087 DQ927088 DQ927090 DQ927091 DQ927092 DQ927093 DQ927094 DQ927096 DQ927097 DQ927098 DQ927099 DQ927100 DQ927101 DQ927102 DQ927104 DQ927105 DQ927107 DQ927110 DQ927111 DQ927113 DQ927117 DQ927120 DQ927121 DQ927122 DQ927123 DQ927124 DQ927125 DQ927126 DQ927127 DQ927128 DQ927130 DQ927131 DQ927133 DQ927134 DQ927135 DQ927136 DQ927137 DQ927138 DQ927139 DQ927140 DQ927141 DQ927143 DQ927144 DQ927145 DQ927146 DQ927147 DQ927148 DQ927149 DQ927150 DQ927151 DQ927152 DQ927153 DQ927154 DQ927155 DQ927156 DQ927157 DQ927158 DQ927159 DQ927160 DQ927161 DQ927162 DQ927163 DQ927164 DQ927165 DQ927166 DQ927167 DQ927168 DQ927169 DQ927170 DQ927171 DQ927172 DQ927173 DQ927174 DQ927175 DQ927176 DQ927177 DQ927179 DQ927180 DQ927181 DQ927183 DQ927184 DQ927186 DQ927187 DQ927188 DQ927189 DQ927190 DQ927191
GenPept AAB86694 AAC96327 AAH74757 AAY24188 ABI48371 ABI48373 ABI48376 ABI48378 ABI48380 ABI48381 ABI48382 ABI48384 ABI48387 ABI48388 ABI48391 ABI48392 ABI48393 ABI48395 ABI48403 ABI48404 ABI48406 ABI48410 ABI48411 ABI48413 ABI48414 ABI48415 ABI48416 ABI48417 ABI48419 ABI48420 ABI48421 ABI48422 ABI48423 ABI48424 ABI48425 ABI48427 ABI48428 ABI48430 ABI48433 ABI48434 ABI48436 ABI48440 ABI48443 ABI48444 ABI48445 ABI48446 ABI48447 ABI48448 ABI48449 ABI48450 ABI48451 ABI48453 ABI48454 ABI48456 ABI48457 ABI48458 ABI48459 ABI48460 ABI48461 ABI48462 ABI48463 ABI48464 ABI48466 ABI48467 ABI48468 ABI48469 ABI48470 ABI48471 ABI48472 ABI48473 ABI48474 ABI48475 ABI48476 ABI48477 ABI48478 ABI48479 ABI48480 ABI48481 ABI48482 ABI48483 ABI48484 ABI48485 ABI48486 ABI48487 ABI48488 ABI48489 ABI48490 ABI48491 ABI48492 ABI48493 ABI48494 ABI48495 ABI48496 ABI48497 ABI48498 ABI48499 ABI48500 ABI48502 ABI48503 ABI48504 ABI48506 ABI48507 ABI48509 ABI48510 ABI48511 ABI48512 ABI48513 ABI48514 BAF84213 EAX10880
RNA Seq Atlas 2660

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca