Homo sapiens Gene: MICA
Summary
InnateDB Gene IDBG-77578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MICA
Gene Name MHC class I polypeptide-related sequence A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000204520
Encoded Proteins
MHC class I polypeptide-related sequence A
MHC class I polypeptide-related sequence A
MHC class I polypeptide-related sequence A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary MICA encodes the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:31399784-31415315
Strand Forward strand
Band p21.33
Transcripts
ENST00000449934 ENSP00000413079
ENST00000421350 ENSP00000402410
ENST00000616296 ENSP00000482382
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0045087 innate immune response
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Natural killer cell mediated cytotoxicity pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.739327
RefSeq NM_001177519 NM_001289152 NM_001289153 NM_001289154
HUGO
OMIM
CCDS CCDS56412 CCDS75421
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas