InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PSAP

Summary

InnateDB Gene

IDBG-77686.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSAP

Gene Name

prosaposin

Synonyms

GLBA; SAP1

Species

Homo sapiens

Ensembl Gene

ENSG00000197746

Encoded Proteins

IDBP-240545

prosaposin

IDBP-240547

prosaposin

IDBP-806603

prosaposin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:71816298-71851369

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000394936	ENSP00000378394
ENST00000394934	ENSP00000378392
ENST00000495196
ENST00000493143
ENST00000610929	ENSP00000480857

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008047	enzyme activator activity
GO:0008289	lipid binding

Biological Process

GO:0002576	platelet degranulation
GO:0006629	lipid metabolic process
GO:0006665	sphingolipid metabolic process
GO:0006687	glycosphingolipid metabolic process
GO:0006869	lipid transport
GO:0007596	blood coagulation
GO:0019216	regulation of lipid metabolic process
GO:0030168	platelet activation
GO:0043085	positive regulation of catalytic activity
GO:0043408	regulation of MAPK cascade
GO:0044281	small molecule metabolic process
GO:0048589	developmental growth
GO:0060736	prostate gland growth
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0071310	cellular response to organic substance

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0016021	integral component of membrane
GO:0043202	lysosomal lumen
GO:0070062	extracellular vesicular exosome