InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: COX7B

Summary

InnateDB Gene

IDBG-77691.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

COX7B

Gene Name

cytochrome c oxidase subunit VIIb

Synonyms

APLCC

Species

Homo sapiens

Ensembl Gene

ENSG00000131174

Encoded Proteins

IDBP-477638

cytochrome c oxidase subunit VIIb

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. [provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:77899438-77907373

Strand

Forward strand

Band

q21.1

Transcripts

ENST00000373335
ENST00000481445	ENSP00000417656
ENST00000475465

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004129	cytochrome-c oxidase activity

Biological Process

GO:0007417	central nervous system development
GO:0022904	respiratory electron transport chain
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005743	mitochondrial inner membrane
GO:0005746	mitochondrial respiratory chain
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031231

View Gene Order

ENSBTAG00000037415

Not yet available

Pathways

NETPATH

REACTOME

REACT_22393

Respiratory electron transport pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_267716

Orphan transporters pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

hsa04260

Cardiac muscle contraction pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.624081

RefSeq

NM_001866

HUGO

OMIM

CCDS

CCDS14437

HPRD

04812

IMGT

EMBL

GenPept

RNA Seq Atlas