Version 5.4
Homo sapiens Gene: HSPD1
Summary
InnateDB Gene IDBG-77925.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSPD1
Gene Name heat shock 60kDa protein 1 (chaperonin)
Synonyms CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HuCHA60; SPG13
Species Homo sapiens
Ensembl Gene ENSG00000144381
Encoded Proteins
IDBP-77927
heat shock 60kDa protein 1 (chaperonin)
IDBP-77931
heat shock 60kDa protein 1 (chaperonin)
IDBP-388175
heat shock 60kDa protein 1 (chaperonin)
IDBP-388177
heat shock 60kDa protein 1 (chaperonin)
IDBP-388179
heat shock 60kDa protein 1 (chaperonin)
IDBP-388180
heat shock 60kDa protein 1 (chaperonin)
IDBP-388181
heat shock 60kDa protein 1 (chaperonin)
IDBP-388182
heat shock 60kDa protein 1 (chaperonin)
IDBP-388183
heat shock 60kDa protein 1 (chaperonin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18575269
HSPD1 is part of the heat shock family of proteins that have many roles in inflammation and regulation of the immune system.
PMID 21145789
HSPD1 plays a dual role as an immune modulator and a biomarker, and is a target to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease.
PMID 21775438
HSPD1 and TLR4 mediate myocardial ischemia-activated innate immune signalling, which plays an important role in mediating apoptosis and inflammation during ischemia/reperfusion (I/R). (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21145789
[Mus musculus] Hspd1 plays a dual role as an immune modulator and a biomarker, and is a target to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease.
PMID 21775438
[Mus musculus] Hspd1 and Tlr4 mediate myocardial ischemia-activated innate immune signalling, which plays an important role in mediating apoptosis and inflammation during ischemia/reperfusion (I/R).
Entrez Gene
Summary This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:197486581-197516737
Strand Reverse strand
Band q33.1
Transcripts
ENST00000345042 ENSP00000340019
ENST00000388968 ENSP00000373620
ENST00000430176 ENSP00000393670
ENST00000452200 ENSP00000412717
ENST00000440114 ENSP00000390404
ENST00000426480 ENSP00000414446
ENST00000428204 ENSP00000396460
ENST00000439605 ENSP00000402478
ENST00000418022 ENSP00000412227
ENST00000491249
ENST00000482167
ENST00000486181
ENST00000476746
ENST00000461097
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 186 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 186 [view]
Protein-Protein 186 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001530 lipopolysaccharide binding
GO:0002039 p53 binding
GO:0003688 DNA replication origin binding
GO:0003697 single-stranded DNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATPase activity
GO:0044822 poly(A) RNA binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0002368 B cell cytokine production
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002842 positive regulation of T cell mediated immune response to tumor cell
GO:0006200 ATP catabolic process
GO:0006458 'de novo' protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 response to unfolded protein
GO:0016032 viral process
GO:0032727 positive regulation of interferon-alpha production
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032735 positive regulation of interleukin-12 production
GO:0032755 positive regulation of interleukin-6 production
GO:0042026 protein refolding
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0043032 positive regulation of macrophage activation
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044267 cellular protein metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0048291 isotype switching to IgG isotypes
GO:0050821 protein stabilization
GO:0050870 positive regulation of T cell activation
GO:0051131 chaperone-mediated protein complex assembly
GO:0051604 protein maturation
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0005769 early endosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 coated pit
GO:0009986 cell surface
GO:0016020 membrane
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex
GO:0030135 coated vesicle
GO:0030141 secretory granule
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
GO:0046696 lipopolysaccharide receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025980
View Gene Order
ENSBTAG00000012586
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04940
Type I diabetes mellitus pathway
hsa03018
RNA degradation pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
toll_endogenous_pathway
Endogenous TLR signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.581438 Hs.655390
RefSeq NM_002156 NM_199440 XM_005246518
HUGO
OMIM
CCDS CCDS33357
HPRD 00318
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca