Version 5.4
Homo sapiens Gene: WFIKKN1
Summary
InnateDB Gene IDBG-7799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WFIKKN1
Gene Name WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127578
Encoded Proteins
IDBP-7801
WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a secreted multidomain protein consisting of a signal peptide, a WAP domain, a follistatin domain, an immunoglobulin domain, two tandem Kunitz domains, and an NTR domain. These domains have been implicated frequently in inhibition of various types of proteases, suggesting that the encoded protein may be a multivalent protease inhibitor and may control the action of multiple types of serine proteases as well as metalloproteinases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:629239-634116
Strand Forward strand
Band p13.3
Transcripts
ENST00000319070 ENSP00000324763
ENST00000573440
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0008191 metalloendopeptidase inhibitor activity
GO:0030414 peptidase inhibitor activity
Biological Process
GO:0001501 skeletal system development
GO:0010951 negative regulation of endopeptidase activity
GO:0032091 negative regulation of protein binding
GO:0043392 negative regulation of DNA binding
GO:0048747 muscle fiber development
GO:0060021 palate development
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071192
View Gene Order
ENSBTAG00000002737
Not yet available
Cross-References
SwissProt Q96NZ8
TrEMBL
UniProt Splice Variant
Entrez Gene 117166
UniGene Hs.345818
RefSeq NM_053284
HUGO HGNC:30912
OMIM 608021
CCDS CCDS10414
HPRD
IMGT
EMBL AE006464 AF422194 AK075356 BC101602 BC101606
GenPept AAI01603 AAI01607 AAK61237 AAL18839 BAC11566
RNA Seq Atlas 117166

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca