InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF9B

Summary

InnateDB Gene

IDBG-77992.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF9B

Gene Name

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000187325

Encoded Proteins

IDBP-77994

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:78129748-78139706

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000341864	ENSP00000339917
ENST00000480681

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006352	DNA-templated transcription, initiation
GO:0030307	positive regulation of cell growth
GO:0043066	negative regulation of apoptotic process
GO:0050821	protein stabilization
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator