InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2C

Summary

InnateDB Gene

IDBG-78076.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2C

Gene Name

ubiquitin-conjugating enzyme E2C

Synonyms

dJ447F3.2; UBCH10

Species

Homo sapiens

Ensembl Gene

ENSG00000175063

Encoded Proteins

IDBP-78078

ubiquitin-conjugating enzyme E2C

IDBP-78082

ubiquitin-conjugating enzyme E2C

IDBP-78084

ubiquitin-conjugating enzyme E2C

IDBP-78086

ubiquitin-conjugating enzyme E2C

IDBP-78088

ubiquitin-conjugating enzyme E2C

IDBP-295682

ubiquitin-conjugating enzyme E2C

IDBP-807051

ubiquitin-conjugating enzyme E2C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:45812576-45816957

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000243893	ENSP00000243893
ENST00000335046	ENSP00000335674
ENST00000356455	ENSP00000348838
ENST00000352551	ENSP00000333975
ENST00000372568	ENSP00000361649
ENST00000405520	ENSP00000385878
ENST00000496085
ENST00000617055	ENSP00000479486

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	75 [view]
Protein-Protein	73 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity

Biological Process

GO:0000278	mitotic cell cycle
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007094	mitotic spindle assembly checkpoint
GO:0008054	cyclin catabolic process
GO:0010458	exit from mitosis
GO:0010994	free ubiquitin chain polymerization
GO:0016567	protein ubiquitination
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031536	positive regulation of exit from mitosis
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051488	activation of anaphase-promoting complex activity
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination