Version 5.4
Homo sapiens Gene: NANS
Summary
InnateDB Gene IDBG-78125.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NANS
Gene Name N-acetylneuraminic acid synthase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000095380
Encoded Proteins
IDBP-78127
N-acetylneuraminic acid synthase
IDBP-376379
N-acetylneuraminic acid synthase
IDBP-376381
N-acetylneuraminic acid synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that functions in the biosynthetic pathways of sialic acids. In vitro, the encoded protein uses N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN), respectively; however, it exhibits much higher activity toward the Neu5Ac phosphate product. In insect cells, expression of this gene results in Neu5Ac and KDN production. This gene is related to the E. coli sialic acid synthase gene neuB, and it can partially restore sialic acid synthase activity in an E. coli neuB-negative mutant. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:98056739-98083075
Strand Forward strand
Band q22.33
Transcripts
ENST00000210444 ENSP00000210444
ENST00000415280 ENSP00000404107
ENST00000427646 ENSP00000404642
ENST00000495319
ENST00000480925
ENST00000461452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008781 N-acylneuraminate cytidylyltransferase activity
GO:0047444 N-acylneuraminate-9-phosphate synthase activity
GO:0050462 N-acetylneuraminate synthase activity
Biological Process
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016051 carbohydrate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028334
View Gene Order
ENSBTAG00000019023
Not yet available
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_200874
Sialic acid metabolism pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
INOH
INOH website
Aminosugars metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.665191
RefSeq NM_018946
HUGO
OMIM
CCDS CCDS6733
HPRD 07285
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca