Homo sapiens Gene: GABBR2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-78321.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | GABBR2 | ||||||||||||||||||||||
Gene Name | gamma-aminobutyric acid (GABA) B receptor, 2 | ||||||||||||||||||||||
Synonyms | GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000136928 | ||||||||||||||||||||||
Encoded Proteins |
gamma-aminobutyric acid (GABA) B receptor, 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 9:98288109-98709197 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q22.33 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
G alpha (i) signalling events pathway
Class C/3 (Metabotropic glutamate/pheromone receptors) pathway
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits pathway
GABA B receptor activation pathway
Activation of G protein gated Potassium channels pathway
Neuronal System pathway
Signaling by GPCR pathway
GABA receptor activation pathway
G protein gated Potassium channels pathway
Activation of GABAB receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Inwardly rectifying K+ channels pathway
Potassium Channels pathway
Transmission across Chemical Synapses pathway
GPCR ligand binding pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | O75899 | ||||||||||||||||||||||
TrEMBL | H9NIL8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 9568 | ||||||||||||||||||||||
UniGene | Hs.198612 Hs.595212 | ||||||||||||||||||||||
RefSeq | NM_005458 XM_005252316 | ||||||||||||||||||||||
HUGO | HGNC:4507 | ||||||||||||||||||||||
OMIM | 607340 | ||||||||||||||||||||||
CCDS | CCDS6736 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AF056085 AF069755 AF074483 AF095784 AF099033 AJ012188 AL353782 AL356282 AL445495 AL591502 BC035071 CH471105 JQ308173 | ||||||||||||||||||||||
GenPept | AAC63228 AAC99345 AAD03336 AAD30389 AAD45867 AAH35071 AFF59483 CAA09942 CAD13322 CAH71298 CAH72233 CAI12581 EAW58890 | ||||||||||||||||||||||
RNA Seq Atlas | 9568 | ||||||||||||||||||||||