InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS6KA6

Summary

InnateDB Gene

IDBG-78452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS6KA6

Gene Name

ribosomal protein S6 kinase, 90kDa, polypeptide 6

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000072133

Encoded Proteins

IDBP-78454

ribosomal protein S6 kinase, 90kDa, polypeptide 6

IDBP-604369

ribosomal protein S6 kinase, 90kDa, polypeptide 6

IDBP-807064

ribosomal protein S6 kinase, 90kDa, polypeptide 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:84058346-84187925

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000262752	ENSP00000262752
ENST00000495332
ENST00000460730
ENST00000543399	ENSP00000440830
ENST00000620340	ENSP00000483896

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0035556	intracellular signal transduction
GO:0045992	negative regulation of embryonic development
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:2000381	negative regulation of mesoderm development