InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSNK2B

Summary

InnateDB Gene

IDBG-78569.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK2B

Gene Name

casein kinase 2, beta polypeptide

Synonyms

CK2B; CK2N; CSK2B; G5A

Species

Homo sapiens

Ensembl Gene

ENSG00000204435

Encoded Proteins

IDBP-78571

casein kinase 2, beta polypeptide

IDBP-78573

casein kinase 2, beta polypeptide

IDBP-78585

casein kinase 2, beta polypeptide

IDBP-78587

casein kinase 2, beta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008]
This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:31665236-31670343

Strand

Forward strand

Band

p21.33

Transcripts

ENST00000375885	ENSP00000365046
ENST00000375882	ENSP00000365042
ENST00000375866	ENSP00000365026
ENST00000375865	ENSP00000365025
ENST00000468255
ENST00000465481
ENST00000481269
ENST00000475875

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 365 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	365 [view]
Protein-Protein	362 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004674	protein serine/threonine kinase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0016301	kinase activity
GO:0019887	protein kinase regulator activity
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007411	axon guidance
GO:0008285	negative regulation of cell proliferation
GO:0010862	positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0016055	Wnt signaling pathway
GO:0016310	phosphorylation
GO:0032927	positive regulation of activin receptor signaling pathway
GO:0033211	adiponectin-activated signaling pathway
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043623	cellular protein complex assembly
GO:0045859	regulation of protein kinase activity
GO:0051101	regulation of DNA binding
GO:0061154	endothelial tube morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005956	protein kinase CK2 complex
GO:0031519	PcG protein complex
GO:0070062	extracellular vesicular exosome