InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SEC24C

Summary

InnateDB Gene

IDBG-78616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SEC24C

Gene Name

SEC24 family, member C (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000176986

Encoded Proteins

IDBP-78618

SEC24 family, member C (S. cerevisiae)

IDBP-78620

SEC24 family, member C (S. cerevisiae)

IDBP-595755

SEC24 family, member C (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The product of this gene may play a role in shaping the vesicle, as well as in cargo selection and concentration. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:73744384-73772161

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000339365	ENSP00000343405
ENST00000345254	ENSP00000321845
ENST00000465076	ENSP00000437000
ENST00000477008
ENST00000496827

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0018279	protein N-linked glycosylation via asparagine
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0048208	COPII vesicle coating
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0030127	COPII vesicle coat
GO:0048471	perinuclear region of cytoplasm