InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STRADB

Summary

InnateDB Gene

IDBG-78683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STRADB

Gene Name

STE20-related kinase adaptor beta

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000082146

Encoded Proteins

IDBP-78685

STE20-related kinase adaptor beta

IDBP-246042

STE20-related kinase adaptor beta

IDBP-388360

STE20-related kinase adaptor beta

IDBP-388362

STE20-related kinase adaptor beta

IDBP-388363

STE20-related kinase adaptor beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:201387858-201480846

Strand

Forward strand

Band

q33.1

Transcripts

ENST00000194530	ENSP00000194530
ENST00000392249	ENSP00000376080
ENST00000458269	ENSP00000409552
ENST00000447698	ENSP00000404359
ENST00000415688	ENSP00000413574
ENST00000488196
ENST00000484098
ENST00000498648
ENST00000468123
ENST00000466770

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0007050	cell cycle arrest
GO:0007254	JNK cascade
GO:0008286	insulin receptor signaling pathway
GO:0032147	activation of protein kinase activity
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand