InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SUMO1

Summary

InnateDB Gene

IDBG-78849.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUMO1

Gene Name

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

Synonyms

DAP1; GMP1; OFC10; PIC1; SENP2; SMT3; SMT3C; SMT3H3; UBL1

Species

Homo sapiens

Ensembl Gene

ENSG00000116030

Encoded Proteins

IDBP-246050

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-246052

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-246054

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-293148

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-293144

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-293146

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-293145

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-293142

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

IDBP-293143

SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:202206180-202238608

Strand

Reverse strand

Band

q33.1

Transcripts

ENST00000392246	ENSP00000376077
ENST00000392245	ENSP00000376076
ENST00000392244	ENSP00000376075
ENST00000409368	ENSP00000387204
ENST00000409627	ENSP00000386500
ENST00000409712	ENSP00000386296
ENST00000409498	ENSP00000386472
ENST00000409205	ENSP00000386267
ENST00000409181	ENSP00000386753
ENST00000469034

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1363 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	1363 [view]
Protein-Protein	1353 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006281	DNA repair
GO:0006355	regulation of transcription, DNA-templated
GO:0016925	protein sumoylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030578	PML body organization
GO:0031334	positive regulation of protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880	regulation of protein localization
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060021	palate development
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0090204	protein localization to nuclear pore

Cellular Component

GO:0001650	fibrillar center
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0030425	dendrite
GO:0031965	nuclear membrane
GO:0045202	synapse