InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLAU

Summary

InnateDB Gene

IDBG-78889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAU

Gene Name

plasminogen activator, urokinase

Synonyms

ATF; BDPLT5; QPD; u-PA; UPA; URK

Species

Homo sapiens

Ensembl Gene

ENSG00000122861

Encoded Proteins

IDBP-78891

plasminogen activator, urokinase

IDBP-380338

plasminogen activator, urokinase

IDBP-810803

plasminogen activator, urokinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer\'s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:73909177-73917497

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000372764	ENSP00000361850
ENST00000446342	ENSP00000388474
ENST00000481390	ENSP00000474318
ENST00000496926
ENST00000494287

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding

Biological Process

GO:0001666	response to hypoxia
GO:0006508	proteolysis
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0010469	regulation of receptor activity
GO:0014909	smooth muscle cell migration
GO:0014910	regulation of smooth muscle cell migration
GO:0033628	regulation of cell adhesion mediated by integrin
GO:0042127	regulation of cell proliferation
GO:0042730	fibrinolysis
GO:0061041	regulation of wound healing
GO:2000097	regulation of smooth muscle cell-matrix adhesion