Version 5.4
Homo sapiens Gene: APOBEC3B
Summary
InnateDB Gene IDBG-7897.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APOBEC3B
Gene Name apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Synonyms A3B; APOBEC1L; ARCD3; ARP4; bK150C2.2; DJ742C19.2; PHRBNL
Species Homo sapiens
Ensembl Gene ENSG00000179750
Encoded Proteins
IDBP-7899
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
IDBP-7901
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
IDBP-293495
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
IDBP-293492
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22108670
Deletion of the APOBEC3B gene strongly impacts susceptibility to Plasmodium falciparum malaria.
Entrez Gene
Summary This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3\' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38982347-38992804
Strand Forward strand
Band q13.1
Transcripts
ENST00000333467 ENSP00000327459
ENST00000335760 ENSP00000338897
ENST00000402182 ENSP00000385060
ENST00000407298 ENSP00000385068
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0008270 zinc ion binding
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0044822 poly(A) RNA binding
GO:0047844 deoxycytidine deaminase activity
Biological Process
GO:0008152 metabolic process
GO:0010529 negative regulation of transposition
GO:0045087 innate immune response (InnateDB)
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9UH17
TrEMBL
UniProt Splice Variant
Entrez Gene 9582
UniGene Hs.226307
RefSeq NM_001270411 NM_004900
HUGO HGNC:17352
OMIM 607110
CCDS CCDS58807 CCDS13982
HPRD 06169
IMGT
EMBL AL022318 AY743217 BC053859 CT841510 U61083 U61084
GenPept AAD00089 AAD00090 AAH53859 AAW31743 CAB45270 CAJ86440 CAQ09851
RNA Seq Atlas 9582

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca