InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRIN3A

Summary

InnateDB Gene

IDBG-79119.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRIN3A

Gene Name

glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000198785

Encoded Proteins

IDBP-79121

glutamate receptor, ionotropic, N-methyl-D-aspartate 3A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:101569353-101738580

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000361820	ENSP00000355155
ENST00000479772

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0016594	glycine binding
GO:0042165	neurotransmitter binding
GO:0042802	identical protein binding
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0006810	transport
GO:0006816	calcium ion transport
GO:0016358	dendrite development
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0045471	response to ethanol
GO:0048511	rhythmic process
GO:0060134	prepulse inhibition
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0045202	synapse
GO:0045211	postsynaptic membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039579

View Gene Order

ENSBTAG00000018445

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

Q8TCU5

TrEMBL

UniProt Splice Variant

Entrez Gene

116443

UniGene

Hs.654783

RefSeq

NM_133445

HUGO

HGNC:16767

OMIM

606650

CCDS

CCDS6758

HPRD

09443

IMGT

EMBL

AB075853 AF416558 AJ416950 AL356516 AL591377 BC167432

GenPept

AAI67432 AAL40734 BAB85559 CAC95229 CAH69962 CAI16651

RNA Seq Atlas

116443