Version 5.4
Homo sapiens Gene: VDAC2
Summary
InnateDB Gene IDBG-79237.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC2
Gene Name voltage-dependent anion channel 2
Synonyms POR
Species Homo sapiens
Ensembl Gene ENSG00000165637
Encoded Proteins
IDBP-79239
voltage-dependent anion channel 2
IDBP-79241
voltage-dependent anion channel 2
IDBP-79243
voltage-dependent anion channel 2
IDBP-79245
voltage-dependent anion channel 2
IDBP-380554
voltage-dependent anion channel 2
IDBP-380556
voltage-dependent anion channel 2
IDBP-598005
voltage-dependent anion channel 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:75210154-75231448
Strand Forward strand
Band q22.2
Transcripts
ENST00000332211 ENSP00000361686
ENST00000298468 ENSP00000298468
ENST00000313132 ENSP00000361635
ENST00000344036 ENSP00000344876
ENST00000447677 ENSP00000401492
ENST00000413289 ENSP00000389551
ENST00000472137
ENST00000470745
ENST00000475142
ENST00000481876
ENST00000498394
ENST00000468285
ENST00000460044
ENST00000543351 ENSP00000443092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 60 [view]
Protein-Protein 57 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0006820 anion transport
GO:0032272 negative regulation of protein polymerization
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0042645 mitochondrial nucleoid
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021771
View Gene Order
ENSBTAG00000012975
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04020
Calcium signaling pathway pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.355927 Hs.605824
RefSeq NM_001184783 NM_001184823 NM_003375 XM_006717961
HUGO
OMIM
CCDS CCDS53544 CCDS7348
HPRD 01904
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca