InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSTF2

Summary

InnateDB Gene

IDBG-79279.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSTF2

Gene Name

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

Synonyms

CstF-64

Species

Homo sapiens

Ensembl Gene

ENSG00000101811

Encoded Proteins

IDBP-79283

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

IDBP-377466

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

IDBP-377468

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

IDBP-589965

cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]
This gene encodes a nuclear protein with an RRM (RNA recognition motif) domain. The protein is a member of the cleavage stimulation factor (CSTF) complex that is involved in the 3\' end cleavage and polyadenylation of pre-mRNAs. Specifically, this protein binds GU-rich elements within the 3\'-untranslated region of mRNAs. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:100820359-100840932

Strand

Forward strand

Band

q22.1

Transcripts

ENST00000372972	ENSP00000362063
ENST00000415585	ENSP00000387996
ENST00000413437	ENSP00000415705
ENST00000475126	ENSP00000432060

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.

Experimentally validated
Total	61 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006379	mRNA cleavage
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing