Version 5.4
Homo sapiens Gene: ABCA1
Summary
InnateDB Gene IDBG-79441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ABCA1
Gene Name ATP-binding cassette, sub-family A (ABC1), member 1
Synonyms ABC-1; ABC1; CERP; HDLDT1; TGD
Species Homo sapiens
Ensembl Gene ENSG00000165029
Encoded Proteins
IDBP-79443
ATP-binding cassette, sub-family A (ABC1), member 1
IDBP-79447
ATP-binding cassette, sub-family A (ABC1), member 1
IDBP-377008
ATP-binding cassette, sub-family A (ABC1), member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20472936
ABCA1 promotes the efflux of bacterial lipopolysaccharide (LPS) from macrophages and accelerates recovery from LPS-induced tolerance.
PMID 20650929
ABCA1 in macrophages dampens inflammation by reducing MYD88-dependent TLR trafficking to lipid rafts, thus selectively reducing free cholesterol content in lipid rafts.
PMID 22955730
ABCA1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes. (Demonstrated in mice)
InnateDB Annotation from Orthologs
Summary
PMID 22955730
[Mus musculus] Abca1 deletion in the myeloid lineage enhances host immune response and clearance of Listeria monocytogenes.
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. With cholesterol as its substrate, this protein functions as a cholesteral efflux pump in the cellular lipid removal pathway. Mutations in this gene have been associated with Tangier\'s disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:104781002-104928237
Strand Reverse strand
Band q31.1
Transcripts
ENST00000374736 ENSP00000363868
ENST00000374733 ENSP00000363865
ENST00000423487 ENSP00000416623
ENST00000494467
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 42 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0005548 phospholipid transporter activity
GO:0008509 anion transmembrane transporter activity
GO:0015485 cholesterol binding
GO:0016887 ATPase activity
GO:0017127 cholesterol transporter activity
GO:0019905 syntaxin binding
GO:0031267 small GTPase binding
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034188 apolipoprotein A-I receptor activity
GO:0051117 ATPase binding
Biological Process
GO:0002790 peptide secretion
GO:0006200 ATP catabolic process
GO:0006497 protein lipidation
GO:0006911 phagocytosis, engulfment
GO:0007040 lysosome organization
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0010745 negative regulation of macrophage derived foam cell differentiation
GO:0010875 positive regulation of cholesterol efflux
GO:0010887 negative regulation of cholesterol storage
GO:0015914 phospholipid transport
GO:0016197 endosomal transport
GO:0030301 cholesterol transport
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032367 intracellular cholesterol transport
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034380 high-density lipoprotein particle assembly
GO:0034616 response to laminar fluid shear stress
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042493 response to drug
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0045332 phospholipid translocation
GO:0050702 interleukin-1 beta secretion
GO:0055091 phospholipid homeostasis
GO:0055098 response to low-density lipoprotein particle stimulus
GO:0060155 platelet dense granule organization
GO:0071222 cellular response to lipopolysaccharide
GO:0071300 cellular response to retinoic acid
GO:0071397 cellular response to cholesterol
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0030139 endocytic vesicle
GO:0034364 high-density lipoprotein particle
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015243
View Gene Order
ENSBTAG00000020661
Not yet available
Pathways
NETPATH
REACTOME
REACT_116145
PPARA activates gene expression pathway
REACT_19241
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
REACT_13621
HDL-mediated lipid transport pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6823
Lipoprotein metabolism pathway
REACT_111217
Metabolism pathway
REACT_602
Lipid digestion, mobilization, and transport pathway
KEGG
hsa02010
ABC transporters pathway
hsa04975
Fat digestion and absorption pathway
INOH
PID NCI
rxr_vdr_pathway
RXR and RAR heterodimerization with other nuclear receptor
Cross-References
SwissProt O95477
TrEMBL B1AMI1 B1AMI2 Q9H002 Q9NP93 Q9NS76
UniProt Splice Variant
Entrez Gene 19
UniGene Hs.659274
RefSeq NM_005502
HUGO HGNC:29
OMIM 600046
CCDS CCDS6762
HPRD
IMGT
EMBL AB037924 AB055982 AF165281 AF165282 AF165283 AF165284 AF165285 AF165286 AF165287 AF165288 AF165289 AF165290 AF165291 AF165292 AF165293 AF165294 AF165295 AF165296 AF165297 AF165298 AF165299 AF165300 AF165301 AF165302 AF165303 AF165304 AF165305 AF165306 AF165307 AF165308 AF165309 AF165310 AF258627 AF275948 AF285167 AF287262 AH009290 AJ012376 AJ252277 AL353685 AL359182 AL359846 CH471105
GenPept AAD49849 AAD49851 AAD49852 AAD49853 AAD49854 AAF69513 AAF69516 AAF86276 AAF98175 AAK43526 BAB07875 BAB63210 CAA10005 CAC21428 CAH72444 CAH73579 EAW58993
RNA Seq Atlas 19

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca