Version 5.4
Homo sapiens Gene: SNAP23
Summary
InnateDB Gene IDBG-7946.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SNAP23
Gene Name synaptosomal-associated protein, 23kDa
Synonyms HsT17016; SNAP-23; SNAP23A; SNAP23B
Species Homo sapiens
Ensembl Gene ENSG00000092531
Encoded Proteins
IDBP-7948
synaptosomal-associated protein, 23kDa
IDBP-7950
synaptosomal-associated protein, 23kDa
IDBP-236013
synaptosomal-associated protein, 23kDa
IDBP-746413
IDBP-747232
IDBP-747581
IDBP-745412
IDBP-746879
IDBP-745202
IDBP-745924
IDBP-747005
IDBP-747181
IDBP-745248
IDBP-744768
IDBP-747379
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18692471
SNAP23 phosphorylation by IKBKB regulates mast cell degranulation and anaphylactic reactions.
Entrez Gene
Summary Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42491233-42545356
Strand Forward strand
Band q15.1
Transcripts
ENST00000249647 ENSP00000249647
ENST00000349777 ENSP00000207062
ENST00000397138 ENSP00000380327
ENST00000566141
ENST00000568859 ENSP00000456035
ENST00000563333
ENST00000563765 ENSP00000457535
ENST00000563451
ENST00000567094 ENSP00000455472
ENST00000561526 ENSP00000454214
ENST00000568227
ENST00000564153 ENSP00000455339
ENST00000568451 ENSP00000454799
ENST00000566327 ENSP00000458012
ENST00000566035 ENSP00000454842
ENST00000568331 ENSP00000455652
ENST00000568514
ENST00000568841 ENSP00000455102
ENST00000568745
ENST00000563830 ENSP00000456000
ENST00000563873 ENSP00000456144
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 68 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006887 exocytosis
GO:0006892 post-Golgi vesicle-mediated transport
GO:0006903 vesicle targeting
GO:0015031 protein transport
GO:0045087 innate immune response (InnateDB)
GO:0061024 membrane organization
GO:0061025 membrane fusion
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0042581 specific granule
GO:0042582 azurophil granule
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027287
View Gene Order
ENSBTAG00000005661
Not yet available
Pathways
NETPATH
REACTOME
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.728237
RefSeq NM_003825 NM_130798
HUGO
OMIM
CCDS CCDS10087 CCDS10088
HPRD 03962
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca