InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IDH1

Summary

InnateDB Gene

IDBG-79725.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IDH1

Gene Name

isocitrate dehydrogenase 1 (NADP+), soluble

Synonyms

HEL-216; HEL-S-26; IDCD; IDH; IDP; IDPC; PICD

Species

Homo sapiens

Ensembl Gene

ENSG00000138413

Encoded Proteins

IDBP-79727

isocitrate dehydrogenase 1 (NADP+), soluble

IDBP-388639

isocitrate dehydrogenase 1 (NADP+), soluble

IDBP-388640

isocitrate dehydrogenase 1 (NADP+), soluble

IDBP-388645

isocitrate dehydrogenase 1 (NADP+), soluble

IDBP-388646

isocitrate dehydrogenase 1 (NADP+), soluble

IDBP-388648

isocitrate dehydrogenase 1 (NADP+), soluble

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008]
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:208236227-208266074

Strand

Reverse strand

Band

q34

Transcripts

ENST00000345146	ENSP00000260985
ENST00000446179	ENSP00000410513
ENST00000415913	ENSP00000390265
ENST00000415282	ENSP00000391075
ENST00000417583	ENSP00000409045
ENST00000451391	ENSP00000396787
ENST00000484575
ENST00000462386
ENST00000481557

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.

Experimentally validated
Total	39 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004450	isocitrate dehydrogenase (NADP+) activity
GO:0005102	receptor binding
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0006097	glyoxylate cycle
GO:0006099	tricarboxylic acid cycle
GO:0006102	isocitrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006740	NADPH regeneration
GO:0006749	glutathione metabolic process
GO:0006979	response to oxidative stress
GO:0008585	female gonad development
GO:0014070	response to organic cyclic compound
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0048545	response to steroid hormone
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005782	peroxisomal matrix
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025950

View Gene Order

ENSBTAG00000020527

Not yet available

Pathways

NETPATH

REACTOME

REACT_16904

NADPH regeneration pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_160183

Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate pathway

REACT_16957

Peroxisomal lipid metabolism pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

KEGG

hsa00020

Citrate cycle (TCA cycle) pathway

hsa00480

Glutathione metabolism pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.593422

RefSeq

NM_001282386 NM_001282387 NM_005896

HUGO

OMIM

CCDS

CCDS2381

HPRD

00984

IMGT

EMBL

GenPept

RNA Seq Atlas