InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NCOA3

Summary

InnateDB Gene

IDBG-79741.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA3

Gene Name

nuclear receptor coactivator 3

Synonyms

ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26; KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1

Species

Homo sapiens

Ensembl Gene

ENSG00000124151

Encoded Proteins

IDBP-79743

nuclear receptor coactivator 3

IDBP-79745

nuclear receptor coactivator 3

IDBP-79747

nuclear receptor coactivator 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Several transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:47501902-47656877

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000372004	ENSP00000361073
ENST00000371998	ENSP00000361066
ENST00000371997	ENSP00000361065
ENST00000490248
ENST00000497292

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	174 [view]
Protein-Protein	154 [view]
Protein-DNA	9 [view]
Protein-RNA	1 [view]
DNA-DNA	10 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257	nuclear hormone receptor binding
GO:0046966	thyroid hormone receptor binding
GO:0046983	protein dimerization activity
GO:0047485	protein N-terminus binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010628	positive regulation of gene expression
GO:0016573	histone acetylation
GO:0030521	androgen receptor signaling pathway
GO:0035264	multicellular organism growth
GO:0035624	receptor transactivation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048589	developmental growth
GO:0060068	vagina development
GO:0060713	labyrinthine layer morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:2001141	regulation of RNA biosynthetic process