InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAD23B

Summary

InnateDB Gene

IDBG-79797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAD23B

Gene Name

RAD23 homolog B (S. cerevisiae)

Synonyms

HHR23B; HR23B; P58

Species

Homo sapiens

Ensembl Gene

ENSG00000119318

Encoded Proteins

IDBP-79799

RAD23 homolog B (S. cerevisiae)

IDBP-377187

RAD23 homolog B (S. cerevisiae)

IDBP-377191

RAD23 homolog B (S. cerevisiae)

IDBP-377192

RAD23 homolog B (S. cerevisiae)

IDBP-377193

RAD23 homolog B (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:107283137-107332194

Strand

Forward strand

Band

q31.2

Transcripts

ENST00000358015	ENSP00000350708
ENST00000419616	ENSP00000416868
ENST00000416373	ENSP00000405623
ENST00000442587	ENSP00000415821
ENST00000457811	ENSP00000396975

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 248 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	248 [view]
Protein-Protein	247 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0000715	nucleotide-excision repair, DNA damage recognition
GO:0000718	nucleotide-excision repair, DNA damage removal
GO:0006281	DNA repair
GO:0006289	nucleotide-excision repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007283	spermatogenesis
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0071942	XPC complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028426

View Gene Order

ENSBTAG00000001926

Not yet available

Pathways

NETPATH

REACTOME

REACT_476

DNA Damage Recognition in GG-NER pathway

REACT_311

Dual incision reaction in GG-NER pathway

REACT_257

Formation of incision complex in GG-NER pathway

REACT_2253

Global Genomic NER (GG-NER) pathway

REACT_1826

Nucleotide Excision Repair pathway

REACT_216

DNA Repair pathway

KEGG

hsa03420

Nucleotide excision repair pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.521640

RefSeq

NM_001244713 NM_001244724 NM_002874

HUGO

OMIM

CCDS

CCDS59138 CCDS6769

HPRD

06772

IMGT

EMBL

GenPept

RNA Seq Atlas