Version 5.4
Homo sapiens Gene: NXF5
Summary
InnateDB Gene IDBG-79944.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NXF5
Gene Name nuclear RNA export factor 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000126952
Encoded Proteins
IDBP-79946
nuclear RNA export factor 5
IDBP-79948
nuclear RNA export factor 5
IDBP-79950
nuclear RNA export factor 5
IDBP-79952
nuclear RNA export factor 5
IDBP-479188
nuclear RNA export factor 5
IDBP-477537
nuclear RNA export factor 5
IDBP-598342
nuclear RNA export factor 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:101832112-101857577
Strand Reverse strand
Band q22.1
Transcripts
ENST00000263032 ENSP00000263032
ENST00000372803 ENSP00000361889
ENST00000332614 ENSP00000331535
ENST00000361330 ENSP00000354539
ENST00000493509 ENSP00000422976
ENST00000473265 ENSP00000426978
ENST00000537026 ENSP00000442401
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006406 mRNA export from nucleus
GO:0007275 multicellular organismal development
GO:0050658 RNA transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
hsa03015
mRNA surveillance pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.307077
RefSeq NM_032946 XM_005262165 XM_005262166 XM_005262167
HUGO
OMIM
CCDS CCDS14491
HPRD 02263
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca