InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: APOBEC3F

Summary

InnateDB Gene

IDBG-7998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APOBEC3F

Gene Name

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000128394

Encoded Proteins

IDBP-8000

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

IDBP-8002

apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21078663

APOBEC3G;APOBEC3F (A3G) is an innate restriction factor that inhibits human immunodeficiency virus type 1 (HIV-1) replication.

Entrez Gene

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:39040604-39053910

Strand

Forward strand

Band

q13.1

Transcripts

ENST00000308521	ENSP00000309749
ENST00000381565	ENSP00000370977
ENST00000491387
ENST00000476513

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	4 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0004126	cytidine deaminase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002230	positive regulation of defense response to virus by host
GO:0009972	cytidine deamination
GO:0010529	negative regulation of transposition
GO:0016553	base conversion or substitution editing
GO:0045071	negative regulation of viral genome replication
GO:0045087	innate immune response (InnateDB)
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0048525	negative regulation of viral process
GO:0051607	defense response to virus
GO:0070383	DNA cytosine deamination
GO:0080111	DNA demethylation

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0030529	ribonucleoprotein complex
GO:0030895	apolipoprotein B mRNA editing enzyme complex

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q8IUX4

TrEMBL

B4DGW8

UniProt Splice Variant

Entrez Gene

200316

UniGene

Hs.659809

RefSeq

NM_145298 NM_001006666

HUGO

HGNC:17356

OMIM

608993

CCDS

CCDS33648 CCDS33649

HPRD

16415

IMGT

EMBL

AK294810 AL022318 BC038808 BC061914 CH471095 CR456395 DQ146365

GenPept

AAH38808 AAH61914 AAZ38720 BAG57929 CAG30281 CAQ09853 EAW60288 EAW60289

RNA Seq Atlas

200316