Homo sapiens Gene: HAUS2
Summary
InnateDB Gene IDBG-8013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HAUS2
Gene Name HAUS augmin-like complex, subunit 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000137814
Encoded Proteins
HAUS augmin-like complex, subunit 2
HAUS augmin-like complex, subunit 2
HAUS augmin-like complex, subunit 2
HAUS augmin-like complex, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary HAUS2 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:42548810-42569994
Strand Forward strand
Band q15.2
Transcripts
ENST00000260372 ENSP00000260372
ENST00000391623 ENSP00000390445
ENST00000562398 ENSP00000455942
ENST00000568846 ENSP00000475743
ENST00000567640 ENSP00000457169
ENST00000570178 ENSP00000455118
ENST00000564279 ENSP00000455104
ENST00000563479 ENSP00000456054
ENST00000568876 ENSP00000456578
ENST00000607467 ENSP00000475909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
Experimentally validated
Total 72 [view]
Protein-Protein 72 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007067 mitotic nuclear division
GO:0031023 microtubule organizing center organization
GO:0051225 spindle assembly
GO:0051297 centrosome organization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005813 centrosome
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0070652 HAUS complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Regulation of PLK1 Activity at G2/M Transition pathway
Loss of Nlp from mitotic centrosomes pathway
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
Recruitment of mitotic centrosome proteins and complexes pathway
Cell Cycle pathway
Centrosome maturation pathway
G2/M Transition pathway
Cell Cycle, Mitotic pathway
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H3BP16
UniProt Splice Variant
Entrez Gene 55142
UniGene Hs.14347 Hs.603340 Hs.613904
RefSeq NM_001130447 NM_018097
HUGO HGNC:25530
OMIM 613429
CCDS CCDS10090 CCDS45247
HPRD 07675
IMGT
EMBL AC018362
GenPept
RNA Seq Atlas 55142