Version 5.4
Homo sapiens Gene: STAU1
Summary
InnateDB Gene IDBG-80162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAU1
Gene Name staufen, RNA binding protein, homolog 1 (Drosophila)
Synonyms PPP1R150; STAU
Species Homo sapiens
Ensembl Gene ENSG00000124214
Encoded Proteins
IDBP-80164
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-80166
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-80170
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-80174
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-80176
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-80178
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-80180
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-378173
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-378177
staufen, RNA binding protein, homolog 1 (Drosophila)
IDBP-806611
staufen double-stranded RNA binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]
Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5\'UTR. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:49113339-49188367
Strand Reverse strand
Band q13.13
Transcripts
ENST00000371856 ENSP00000360922
ENST00000340954 ENSP00000345425
ENST00000371828 ENSP00000360893
ENST00000360426 ENSP00000353604
ENST00000371802 ENSP00000360867
ENST00000347458 ENSP00000323443
ENST00000371792 ENSP00000360857
ENST00000437404 ENSP00000416779
ENST00000456866 ENSP00000398785
ENST00000614381 ENSP00000484011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 307 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 307 [view]
Protein-Protein 304 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0005515 protein binding
GO:0008157 protein phosphatase 1 binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008298 intracellular mRNA localization
Cellular Component
GO:0005737 cytoplasm
GO:0005791 rough endoplasmic reticulum
GO:0005875 microtubule associated complex
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030425 dendrite
GO:0030529 ribonucleoprotein complex
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039536
View Gene Order
ENSBTAG00000000241
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596704 Hs.713716 Hs.714254
RefSeq NM_001037328 NM_004602 NM_017452 NM_017453 NM_017454 XM_005260524 XM_005260525 XM_005260526 XM_005260527 XM_005260528 XM_005260529 XM_006723865 XM_006723866 XM_006723867 XM_006723868 XM_006723869
HUGO
OMIM
CCDS CCDS13414 CCDS13415 CCDS33481
HPRD 03422
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca