InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STUB1

Summary

InnateDB Gene

IDBG-8030.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STUB1

Gene Name

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

Synonyms

CHIP; HSPABP2; NY-CO-7; SCAR16; SDCCAG7; UBOX1

Species

Homo sapiens

Ensembl Gene

ENSG00000103266

Encoded Proteins

IDBP-8032

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

IDBP-746150

IDBP-751287

IDBP-749796

IDBP-747163

IDBP-750731

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21911421

STUB1 facilitates the formation of a TLR signalling complex by recruiting, ubiquitinating, and activating Src and PRKCZ. Knockdown of Stub1 in mice inhibits Tlr4- and Tlr9-signalling pathways. (Demonstrated in mice)

InnateDB Annotation from Orthologs

Summary

PMID 21911421

[Mus musculus] Stub1 facilitates the formation of a TLR signalling complex by recruiting, ubiquitinating, and activating Src and Prkcz. Knockdown of Stub1 inhibits Tlr4- and Tlr9-signalling pathways.

Entrez Gene

Summary

STUB1, or CHIP, is a ubiquitin ligase/cochaperone that participates in protein quality control by targeting a broad range of chaperone protein substrates for degradation (Min et al., 2008 [PubMed 18411298]).[supplied by OMIM, Jul 2009]
This gene encodes a protein containing tetratricopeptide repeat and a U-box that functions as a ubiquitin ligase/cochaperone. The encoded protein binds to and ubiquitinates shock cognate 71 kDa protein (Hspa8) and DNA polymerase beta (Polb), among other targets. Mutations in this gene cause spinocerebellar ataxia, autosomal recessive 16. Alternative splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 2. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:680224-682870

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000219548	ENSP00000219548
ENST00000567790
ENST00000566408	ENSP00000457583
ENST00000569248
ENST00000564370	ENSP00000456875
ENST00000566181
ENST00000565677	ENSP00000457228
ENST00000563505
ENST00000564316	ENSP00000457090
ENST00000567173	ENSP00000456591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 331 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	331 [view]
Protein-Protein	328 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0019899	enzyme binding
GO:0019900	kinase binding
GO:0030544	Hsp70 protein binding
GO:0030674	protein binding, bridging
GO:0030911	TPR domain binding
GO:0031625	ubiquitin protein ligase binding
GO:0034450	ubiquitin-ubiquitin ligase activity
GO:0042803	protein homodimerization activity
GO:0046332	SMAD binding
GO:0051787	misfolded protein binding
GO:0051879	Hsp90 protein binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006281	DNA repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006515	misfolded or incompletely synthesized protein catabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0016567	protein ubiquitination
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030579	ubiquitin-dependent SMAD protein catabolic process
GO:0031398	positive regulation of protein ubiquitination
GO:0031943	regulation of glucocorticoid metabolic process
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051604	protein maturation
GO:0051865	protein autoubiquitination
GO:0070534	protein K63-linked ubiquitination
GO:0071218	cellular response to misfolded protein
GO:0090035	positive regulation of chaperone-mediated protein complex assembly

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031371	ubiquitin conjugating enzyme complex
GO:0042405	nuclear inclusion body
GO:0045111	intermediate filament cytoskeleton
GO:0070062	extracellular vesicular exosome