Version 5.4
Homo sapiens Gene: DDX27
Summary
InnateDB Gene IDBG-80385.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX27
Gene Name DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124228
Encoded Proteins
IDBP-80387
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
IDBP-812526
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
IDBP-812527
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
IDBP-812525
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
IDBP-812530
DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:49219295-49244077
Strand Forward strand
Band q13.13
Transcripts
ENST00000371764 ENSP00000360828
ENST00000484427
ENST00000462328 ENSP00000481808
ENST00000493252 ENSP00000483119
ENST00000471144
ENST00000618172 ENSP00000482680
ENST00000622530 ENSP00000483495
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0016787 hydrolase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017999
View Gene Order
ENSBTAG00000006671
Not yet available
Cross-References
SwissProt Q96GQ7
TrEMBL B7Z6D5
UniProt Splice Variant
Entrez Gene 55661
UniGene Hs.65234
RefSeq NM_017895 XM_006723815
HUGO HGNC:15837
OMIM
CCDS CCDS13416
HPRD
IMGT
EMBL AF161377 AF193054 AF336851 AK000603 AK022979 AK300135 AL049766 AL357560 AY044431 BC009304 BC011927 BC016060 BC126287 BC130275 BC144125
GenPept AAF28937 AAG22482 AAH09304 AAH11927 AAH16060 AAI26288 AAI30276 AAI44126 AAK21271 AAK95821 BAA91284 BAB14343 BAH13221 CAH70236 CAI22427
RNA Seq Atlas 55661

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca