Version 5.4
Homo sapiens Gene: AGER
Summary
InnateDB Gene IDBG-80463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AGER
Gene Name advanced glycosylation end product-specific receptor
Synonyms RAGE
Species Homo sapiens
Ensembl Gene ENSG00000204305
Encoded Proteins
IDBP-80465
advanced glycosylation end product-specific receptor
IDBP-80467
advanced glycosylation end product-specific receptor
IDBP-80469
advanced glycosylation end product-specific receptor
IDBP-80471
advanced glycosylation end product-specific receptor
IDBP-80473
advanced glycosylation end product-specific receptor
IDBP-80479
advanced glycosylation end product-specific receptor
IDBP-80481
advanced glycosylation end product-specific receptor
IDBP-374279
advanced glycosylation end product-specific receptor
IDBP-374281
advanced glycosylation end product-specific receptor
IDBP-587270
advanced glycosylation end product-specific receptor
IDBP-809252
advanced glycosylation end product-specific receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22386596
AGER is a native receptor for complement component C1QA.
InnateDB Annotation from Orthologs
Summary
PMID 22386596
[Mus musculus] Ager is a native receptor for complement component C1qa. (Demonstrated in human)
PMID 25911757
[Mus musculus] S100a8/S100a9 are proinflammatory proteins that activate natural killer cells via Ager signalling.
Entrez Gene
Summary The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor, and besides AGE, interacts with other molecules implicated in homeostasis, development, and inflammation, and certain diseases, such as diabetes and Alzheimer\'s disease. Many alternatively spliced transcript variants encoding different isoforms, as well as non-protein-coding variants, have been described for this gene (PMID:18089847). [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32180968-32184324
Strand Reverse strand
Band p21.32
Transcripts
ENST00000375076 ENSP00000364217
ENST00000375070 ENSP00000364211
ENST00000375069 ENSP00000364210
ENST00000375067 ENSP00000364208
ENST00000375065 ENSP00000364206
ENST00000375056 ENSP00000364196
ENST00000375055 ENSP00000364195
ENST00000438221 ENSP00000387887
ENST00000450110 ENSP00000398466
ENST00000469940
ENST00000484849
ENST00000488669
ENST00000473619
ENST00000538695 ENSP00000445389
ENST00000620802 ENSP00000484081
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004872 receptor activity
GO:0004888 transmembrane signaling receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044548 S100 protein binding
Biological Process
GO:0006954 inflammatory response
GO:0007166 cell surface receptor signaling pathway
GO:0009611 response to wounding
GO:0031175 neuron projection development
GO:0045087 innate immune response (InnateDB)
GO:0050930 induction of positive chemotaxis
GO:0051092 positive regulation of NF-kappaB transcription factor activity
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015452
View Gene Order
ENSBTAG00000014420
Not yet available
Pathways
NETPATH
REACTOME
REACT_118563
RIP-mediated NFkB activation via ZBP1 pathway
REACT_118764
ZBP1(DAI) mediated induction of type I IFNs pathway
REACT_24969
TRAF6 mediated NF-kB activation pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_25195
Advanced glycosylation endproduct receptor signaling pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_6802
Innate Immune System pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_163773
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
REACT_6900
Immune System pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
KEGG
INOH
PID NCI
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.534342
RefSeq NM_001136 NM_001206929 NM_001206932 NM_001206934 NM_001206936 NM_001206940 NM_001206954 NM_001206966 NM_172197
HUGO
OMIM
CCDS CCDS4746 CCDS4747 CCDS56417 CCDS56418 CCDS75429
HPRD 02568
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca