Homo sapiens Gene: PTGIS | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-80513.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | PTGIS | ||||||||||||||||||||||||||||||||||
Gene Name | prostaglandin I2 (prostacyclin) synthase | ||||||||||||||||||||||||||||||||||
Synonyms | CYP8; CYP8A1; PGIS; PTGI | ||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000124212 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
prostaglandin I2 (prostacyclin) synthase
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 20:49503874-49568146 | ||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||
Band | q13.13 | ||||||||||||||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Synthesis of bile acids and bile salts via 24-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol pathway
Synthesis of bile acids and bile salts via 27-hydroxycholesterol pathway
Synthesis of bile acids and bile salts pathway
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
Arachidonic acid metabolism pathway
Nicotinamide salvaging pathway
Nicotinate metabolism pathway
Sterols are 12-hydroxylated by CYP8B1 pathway
Endogenous sterols pathway
Eicosanoids pathway
Metabolism of lipids and lipoproteins pathway
Defective HLCS causes multiple carboxylase deficiency pathway
Defective MUT causes methylmalonic aciduria mut type pathway
Defective MMAA causes methylmalonic aciduria type cblA pathway
Defective TCN2 causes hereditary megaloblastic anemia pathway
Bile acid and bile salt metabolism pathway
Metabolism of water-soluble vitamins and cofactors pathway
Defective AMN causes hereditary megaloblastic anemia 1 pathway
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
Defective CD320 causes methylmalonic aciduria pathway
Defects in cobalamin (B12) metabolism pathway
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
Defects in biotin (Btn) metabolism pathway
Cytochrome P450 - arranged by substrate type pathway
Defective BTD causes biotidinase deficiency pathway
Defective GIF causes intrinsic factor deficiency pathway
Defects in vitamin and cofactor metabolism pathway
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
Metabolism pathway
Defective MMAB causes methylmalonic aciduria type cblB pathway
Biological oxidations pathway
Disease pathway
Phase 1 - Functionalization of compounds pathway
Metabolism of vitamins and cofactors pathway
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KEGG |
Arachidonic acid metabolism pathway
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INOH |
Prostaglandin Leukotriene metabolism pathway
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PID NCI | |||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | Q16647 | ||||||||||||||||||||||||||||||||||
TrEMBL | Q6LEN0 | ||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | 5740 | ||||||||||||||||||||||||||||||||||
UniGene | Hs.302085 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_000961 | ||||||||||||||||||||||||||||||||||
HUGO | HGNC:9603 | ||||||||||||||||||||||||||||||||||
OMIM | 601699 | ||||||||||||||||||||||||||||||||||
CCDS | CCDS13419 | ||||||||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | AF297048 AF297049 AF297050 AF297051 AF297052 AL118525 BC101809 BC101811 D38145 D84124 | ||||||||||||||||||||||||||||||||||
GenPept | AAG31781 AAG31782 AAG31783 AAG31784 AAG31785 AAI01810 AAI01812 BAA07343 BAA28219 CAC14162 | ||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 5740 | ||||||||||||||||||||||||||||||||||