InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: XRCC5

Summary

InnateDB Gene

IDBG-80616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

XRCC5

Gene Name

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Synonyms

KARP-1; KARP1; KU80; Ku86; KUB2; NFIV

Species

Homo sapiens

Ensembl Gene

ENSG00000079246

Encoded Proteins

IDBP-246273

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

IDBP-246275

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

IDBP-388819

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

IDBP-388820

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24098118

Vaccinia virus protein C16 influences the immune response by binding to the XRCC6/XRCC5 (Ku70/80) complex thus blocking PRKDC-dependent DNA sensing in fibroblasts

Entrez Gene

Summary

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:216107464-216206303

Strand

Forward strand

Band

q35

Transcripts

ENST00000392133	ENSP00000375978
ENST00000392132	ENSP00000375977
ENST00000429133
ENST00000417391	ENSP00000401318
ENST00000451695	ENSP00000395108
ENST00000476360
ENST00000460284
ENST00000493706
ENST00000471649
ENST00000485763

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 241 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	241 [view]
Protein-Protein	234 [view]
Protein-DNA	6 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003690	double-stranded DNA binding
GO:0003691	double-stranded telomeric DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0031625	ubiquitin protein ligase binding
GO:0042162	telomeric DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0044822	poly(A) RNA binding
GO:0051575	5'-deoxyribose-5-phosphate lyase activity

Biological Process

GO:0000723	telomere maintenance
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0006351	transcription, DNA-templated
GO:0007420	brain development
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0032481	positive regulation of type I interferon production
GO:0032508	DNA duplex unwinding
GO:0042493	response to drug
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050769	positive regulation of neurogenesis
GO:0060218	hematopoietic stem cell differentiation
GO:0071398	cellular response to fatty acid
GO:0071475	cellular hyperosmotic salinity response
GO:0071481	cellular response to X-ray
GO:0075713	establishment of integrated proviral latency

Cellular Component

GO:0000783	nuclear telomere cap complex
GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0043234	protein complex
GO:0043564	Ku70:Ku80 complex
GO:0070419	nonhomologous end joining complex