InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNAI1

Summary

InnateDB Gene

IDBG-80676.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNAI1

Gene Name

snail homolog 1 (Drosophila)

Synonyms

dJ710H13.1; SLUGH2; SNA; SNAH; SNAIL; SNAIL1

Species

Homo sapiens

Ensembl Gene

ENSG00000124216

Encoded Proteins

IDBP-80678

snail homolog 1 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:49982999-49988886

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000244050

ENSP00000244050

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	58 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001649	osteoblast differentiation
GO:0001707	mesoderm formation
GO:0001837	epithelial to mesenchymal transition
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007498	mesoderm development
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010957	negative regulation of vitamin D biosynthetic process
GO:0016477	cell migration
GO:0030335	positive regulation of cell migration
GO:0031069	hair follicle morphogenesis
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0060021	palate development
GO:0060536	cartilage morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development
GO:0060972	left/right pattern formation
GO:0061314	Notch signaling involved in heart development
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042821

View Gene Order

ENSBTAG00000014554

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04520

Adherens junction pathway

INOH

PID NCI

met_pathway

Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

myc_activpathway

Validated targets of C-MYC transcriptional activation

ilk_pathway

Integrin-linked kinase signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.48029

RefSeq

NM_005985

HUGO

OMIM

CCDS

CCDS13423

HPRD

05025

IMGT

EMBL

GenPept

RNA Seq Atlas