Version 5.4
Homo sapiens Gene: TNP1
Summary
InnateDB Gene IDBG-80761.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNP1
Gene Name transition protein 1 (during histone to protamine replacement)
Synonyms TP1
Species Homo sapiens
Ensembl Gene ENSG00000118245
Encoded Proteins
IDBP-80763
transition protein 1 (during histone to protamine replacement)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transition protein-1 is a spermatid-specific product of the haploid genome which replaces histone and is itself replaced in the mature sperm by the protamines (see PRM1, MIM 182880; PRM2, MIM 182890) (Luerssen et al., 1990 [PubMed 2249851]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:216859458-216860064
Strand Reverse strand
Band q35
Transcripts
ENST00000236979 ENSP00000236979
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0000012 single strand break repair
GO:0006337 nucleosome disassembly
GO:0006338 chromatin remodeling
GO:0006342 chromatin silencing
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0007286 spermatid development
GO:0007289 spermatid nucleus differentiation
GO:0007290 spermatid nucleus elongation
GO:0019953 sexual reproduction
GO:0030317 sperm motility
GO:0035042 fertilization, exchange of chromosomal proteins
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000786 nucleosome
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026182
View Gene Order
ENSBTAG00000019003
Not yet available
Cross-References
SwissProt P09430
TrEMBL Q4ZG82
UniProt Splice Variant
Entrez Gene 7141
UniGene Hs.3017
RefSeq NM_003284
HUGO HGNC:11951
OMIM 190231
CCDS CCDS2406
HPRD
IMGT
EMBL AB281700 AC007557 BC029516 CH471063 M59924 X07948
GenPept AAA61202 AAH29516 AAX88913 BAF36709 CAA30774 EAW70577
RNA Seq Atlas 7141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca