Homo sapiens Gene: GPBAR1 | |||||||||
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Summary | |||||||||
InnateDB Gene | IDBG-80852.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | GPBAR1 | ||||||||
Gene Name | G protein-coupled bile acid receptor 1 | ||||||||
Synonyms | |||||||||
Species | Homo sapiens | ||||||||
Ensembl Gene | ENSG00000179921 | ||||||||
Encoded Proteins |
G protein-coupled bile acid receptor 1
G protein-coupled bile acid receptor 1
G protein-coupled bile acid receptor 1
G protein-coupled bile acid receptor 1
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Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
Entrez Gene | |||||||||
Summary |
This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 2:218259496-218263859 | ||||||||
Strand | Forward strand | ||||||||
Band | q35 | ||||||||
Transcripts |
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Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||
NETPATH | |||||||||
REACTOME |
G alpha (s) signalling events pathway
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Signal Transduction pathway
GPCR downstream signaling pathway
GPCR ligand binding pathway
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KEGG | |||||||||
INOH | |||||||||
PID NCI | |||||||||
Cross-References | |||||||||
SwissProt | |||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | |||||||||
UniGene | Hs.160954 | ||||||||
RefSeq | NM_001077191 NM_001077194 NM_170699 | ||||||||
HUGO | |||||||||
OMIM | |||||||||
CCDS | CCDS46515 | ||||||||
HPRD | 17050 | ||||||||
IMGT | |||||||||
EMBL | |||||||||
GenPept | |||||||||
RNA Seq Atlas | |||||||||