InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PTPN1

Summary

InnateDB Gene

IDBG-80957.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN1

Gene Name

protein tyrosine phosphatase, non-receptor type 1

Synonyms

PTP1B

Species

Homo sapiens

Ensembl Gene

ENSG00000196396

Encoded Proteins

IDBP-80959

protein tyrosine phosphatase, non-receptor type 1

IDBP-595103

protein tyrosine phosphatase, non-receptor type 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:50510321-50585241

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000371621	ENSP00000360683
ENST00000541713	ENSP00000437732

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 170 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	170 [view]
Protein-Protein	167 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004725	protein tyrosine phosphatase activity
GO:0005158	insulin receptor binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016791	phosphatase activity
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0030971	receptor tyrosine kinase binding
GO:0044822	poly(A) RNA binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0007596	blood coagulation
GO:0008286	insulin receptor signaling pathway
GO:0009966	regulation of signal transduction
GO:0016311	dephosphorylation
GO:0019221	cytokine-mediated signaling pathway
GO:0030100	regulation of endocytosis
GO:0030168	platelet activation
GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0031532	actin cytoskeleton reorganization
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway
GO:0046626	regulation of insulin receptor signaling pathway
GO:0046627	negative regulation of insulin receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060334	regulation of interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway
GO:0060338	regulation of type I interferon-mediated signaling pathway
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway
GO:1990264	peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity

Cellular Component

GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0097443	sorting endosome