Version 5.4
Homo sapiens Gene: PARD6B
Summary
InnateDB Gene IDBG-81030.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARD6B
Gene Name par-6 partitioning defective 6 homolog beta (C. elegans)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000124171
Encoded Proteins
IDBP-81032
par-6 partitioning defective 6 homolog beta (C. elegans)
IDBP-238340
par-6 partitioning defective 6 homolog beta (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:50731544-50756795
Strand Forward strand
Band q13.13
Transcripts
ENST00000371610 ENSP00000360672
ENST00000396039 ENSP00000379354
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 33 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0007043 cell-cell junction assembly
GO:0007049 cell cycle
GO:0007163 establishment or maintenance of cell polarity
GO:0007409 axonogenesis
GO:0030334 regulation of cell migration
GO:0034329 cell junction assembly
GO:0045216 cell-cell junction organization
GO:0051301 cell division
GO:0070830 tight junction assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005923 tight junction
GO:0005938 cell cortex
GO:0043234 protein complex
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000044641
View Gene Order
ENSBTAG00000021601
Not yet available
Pathways
NETPATH
REACTOME
REACT_19373
Tight junction interactions pathway
REACT_111155
Cell-Cell communication pathway
REACT_20676
Cell junction organization pathway
REACT_19331
Cell-cell junction organization pathway
KEGG
hsa04530
Tight junction pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.589848 Hs.629055
RefSeq NM_032521
HUGO
OMIM
CCDS CCDS33485
HPRD 18703
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca