Version 5.4
Homo sapiens Gene: ADNP
Summary
InnateDB Gene IDBG-81086.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADNP
Gene Name activity-dependent neuroprotector homeobox
Synonyms ADNP1; MRD28
Species Homo sapiens
Ensembl Gene ENSG00000101126
Encoded Proteins
IDBP-81088
activity-dependent neuroprotector homeobox
IDBP-81090
activity-dependent neuroprotector homeobox
IDBP-238354
activity-dependent neuroprotector homeobox
IDBP-238356
activity-dependent neuroprotector homeobox
IDBP-593679
activity-dependent neuroprotector homeobox
IDBP-812163
activity-dependent neuroprotector homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:50888919-50931240
Strand Reverse strand
Band q13.13
Transcripts
ENST00000349014 ENSP00000342905
ENST00000371602 ENSP00000360662
ENST00000396032 ENSP00000379349
ENST00000396029 ENSP00000379346
ENST00000534467 ENSP00000436181
ENST00000621696 ENSP00000483881
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0043524 negative regulation of neuron apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051149
View Gene Order
ENSBTAG00000000340
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.570355 Hs.618064 Hs.743635
RefSeq NM_001282531 NM_001282532 NM_015339 NM_181442 XM_006723759
HUGO
OMIM
CCDS CCDS13433
HPRD 09793
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca