Homo sapiens Gene: PRKAG3 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-81160.5 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PRKAG3 | ||||||||||||||||||
Gene Name | protein kinase, AMP-activated, gamma 3 non-catalytic subunit | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000115592 | ||||||||||||||||||
Encoded Proteins |
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
protein kinase, AMP-activated, gamma 3 non-catalytic subunit
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:218822383-218832086 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q35 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Regulation of Rheb GTPase activity by AMPK pathway
Regulation of AMPK activity via LKB1 pathway
mTOR signalling pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
Translocation of GLUT4 to the plasma membrane pathway
Energy dependent regulation of mTOR by LKB1-AMPK pathway
Organelle biogenesis and maintenance pathway
PKB-mediated events pathway
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
Mitochondrial biogenesis pathway
Signal Transduction pathway
IRS-mediated signalling pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IGF1R signaling cascade pathway
Membrane Trafficking pathway
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KEGG |
Circadian rhythm pathway
Insulin signaling pathway pathway
Adipocytokine signaling pathway pathway
Hypertrophic cardiomyopathy (HCM) pathway
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INOH |
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
VEGF signaling pathway pathway
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PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | Q9UGI9 | ||||||||||||||||||
TrEMBL | A0A024R426 B4DT70 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 53632 | ||||||||||||||||||
UniGene | Hs.591634 | ||||||||||||||||||
RefSeq | NM_017431 | ||||||||||||||||||
HUGO | HGNC:9387 | ||||||||||||||||||
OMIM | 604976 | ||||||||||||||||||
CCDS | CCDS2424 | ||||||||||||||||||
HPRD | 16085 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC009974 AF214519 AJ249977 AK300078 BC098102 BC098255 BC098277 BC098306 CH471063 | ||||||||||||||||||
GenPept | AAF73987 AAH98102 AAH98255 AAH98277 AAH98306 BAG61882 CAB65117 EAW70656 EAW70657 | ||||||||||||||||||
RNA Seq Atlas | 53632 | ||||||||||||||||||