Version 5.4
Homo sapiens Gene: RNF128
Summary
InnateDB Gene IDBG-81193.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RNF128
Gene Name ring finger protein 128, E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133135
Encoded Proteins
IDBP-81195
ring finger protein 128
IDBP-81199
ring finger protein 128
IDBP-378657
ring finger protein 128
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:106693794-106796993
Strand Forward strand
Band q22.3
Transcripts
ENST00000324342 ENSP00000316127
ENST00000255499 ENSP00000255499
ENST00000418562 ENSP00000412610
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination
GO:0042036 negative regulation of cytokine biosynthetic process
Cellular Component
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0016021 integral component of membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031438
View Gene Order
ENSBTAG00000022920
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Cross-References
SwissProt
TrEMBL Q5JSK4
UniProt Splice Variant
Entrez Gene 79589
UniGene Hs.496542
RefSeq NM_024539 NM_194463
HUGO HGNC:21153
OMIM 300439
CCDS CCDS14520 CCDS14521
HPRD 02340
IMGT
EMBL AL391315 AL606833
GenPept
RNA Seq Atlas 79589

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca