Version 5.4
Homo sapiens Gene: PPP4R1
Summary
InnateDB Gene IDBG-812.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP4R1
Gene Name protein phosphatase 4, regulatory subunit 1
Synonyms MEG1; PP4(Rmeg); PP4R1
Species Homo sapiens
Ensembl Gene ENSG00000154845
Encoded Proteins
IDBP-814
protein phosphatase 4, regulatory subunit 1
IDBP-227937
protein phosphatase 4, regulatory subunit 1
IDBP-227939
protein phosphatase 4, regulatory subunit 1
IDBP-728018
IDBP-725638
IDBP-727053
IDBP-727621
IDBP-727369
IDBP-727538
IDBP-726212
IDBP-728106
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:9546791-9615240
Strand Reverse strand
Band p11.22
Transcripts
ENST00000285124 ENSP00000285124
ENST00000400556 ENSP00000383402
ENST00000400555 ENSP00000383401
ENST00000583092 ENSP00000462485
ENST00000580283
ENST00000578010
ENST00000583903
ENST00000584074 ENSP00000463459
ENST00000579638
ENST00000582594
ENST00000578329
ENST00000580583
ENST00000577393
ENST00000580182 ENSP00000464394
ENST00000584754
ENST00000583988
ENST00000578557
ENST00000578178
ENST00000583438
ENST00000581250 ENSP00000462399
ENST00000579609
ENST00000580745 ENSP00000463345
ENST00000577779
ENST00000582240 ENSP00000463909
ENST00000582933
ENST00000579415
ENST00000581835 ENSP00000462161
ENST00000577667
ENST00000578875 ENSP00000462621
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 18 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004721 phosphoprotein phosphatase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0030362 protein phosphatase type 4 regulator activity
Biological Process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016311 dephosphorylation
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0030289 protein phosphatase 4 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061950
View Gene Order
ENSBTAG00000009822
Not yet available
Cross-References
SwissProt
TrEMBL J3KRU1 J3QL26
UniProt Splice Variant
Entrez Gene 9989
UniGene Hs.743236
RefSeq NM_001042388 NM_005134
HUGO HGNC:9320
OMIM 604908
CCDS CCDS42412 CCDS42413
HPRD
IMGT
EMBL AP000902 AP001381
GenPept
RNA Seq Atlas 9989

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca