Homo sapiens Gene: NFATC2 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Gene | IDBG-81223.6 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | NFATC2 | ||||||||||||||||||||||||||||
Gene Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | ||||||||||||||||||||||||||||
Synonyms | NFAT1; NFATP | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000101096 | ||||||||||||||||||||||||||||
Encoded Proteins |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
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Protein Structure | |||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||
Summary |
NFATC2 interacts with JUN to synergistically activate interleukin-2 (IL2) transcription in T cells, a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumourigenesis.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||
Summary |
[Mus musculus] Nfatc2 is a cytokine that acts as an autocrine growth factor during an immune response to bacterial and viral infection, as well as tumorigenesis.
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Entrez Gene | |||||||||||||||||||||||||||||
Summary |
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Apr 2012] |
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Gene Information | |||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||
Genomic Location | Chromosome 20:51386957-51562831 | ||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||
Band | q13.2 | ||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||
NETPATH |
KitReceptor pathway
Wnt pathway
TCR pathway
BCR pathway
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REACTOME |
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
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KEGG |
VEGF signaling pathway pathway
Wnt signaling pathway pathway
Axon guidance pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
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INOH | |||||||||||||||||||||||||||||
PID NCI |
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Noncanonical Wnt signaling pathway
Fc-epsilon receptor I signaling in mast cells
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Cross-References | |||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||
UniGene | |||||||||||||||||||||||||||||
RefSeq | NM_001136021 NM_001258292 NM_001258294 NM_001258295 NM_001258296 NM_001258297 NM_012340 NM_173091 XM_005260413 | ||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||
CCDS | CCDS13437 CCDS33488 CCDS46614 CCDS68156 CCDS68157 | ||||||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||