InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IHH

Summary

InnateDB Gene

IDBG-81274.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IHH

Gene Name

Indian hedgehog

Synonyms

BDA1; HHG2

Species

Homo sapiens

Ensembl Gene

ENSG00000163501

Encoded Proteins

IDBP-81276

Indian hedgehog

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the hedgehog family of secreted signaling molecules. Hedgehog proteins are essential regulators of a variety of developmental processes including growth, patterning and morphogenesis. The encoded protein specifically plays a role in bone growth an differentiation. Mutations in this gene are the cause of brachydactyly type A1 which is characterized by shortening or malformation of the phalanges. Mutations in this gene are also the cause of acrocapitofemoral dysplasia. [provided by RefSeq, Feb 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:219054420-219060467

Strand

Reverse strand

Band

q35

Transcripts

ENST00000295731

ENSP00000295731

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005113	patched binding
GO:0005509	calcium ion binding
GO:0008233	peptidase activity

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001569	patterning of blood vessels
GO:0001649	osteoblast differentiation
GO:0001701	in utero embryonic development
GO:0001708	cell fate specification
GO:0001763	morphogenesis of a branching structure
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0003382	epithelial cell morphogenesis
GO:0003406	retinal pigment epithelium development
GO:0006029	proteoglycan metabolic process
GO:0006508	proteolysis
GO:0007154	cell communication
GO:0007224	smoothened signaling pathway
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0007389	pattern specification process
GO:0008284	positive regulation of cell proliferation
GO:0009880	embryonic pattern specification
GO:0009968	negative regulation of signal transduction
GO:0016539	intein-mediated protein splicing
GO:0030154	cell differentiation
GO:0030704	vitelline membrane formation
GO:0031016	pancreas development
GO:0032332	positive regulation of chondrocyte differentiation
GO:0032355	response to estradiol
GO:0032967	positive regulation of collagen biosynthetic process
GO:0033085	negative regulation of T cell differentiation in thymus
GO:0033088	negative regulation of immature T cell proliferation in thymus
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0035264	multicellular organism growth
GO:0035988	chondrocyte proliferation
GO:0040008	regulation of growth
GO:0043010	camera-type eye development
GO:0043066	negative regulation of apoptotic process
GO:0045453	bone resorption
GO:0045595	regulation of cell differentiation
GO:0045596	negative regulation of cell differentiation
GO:0045880	positive regulation of smoothened signaling pathway
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0046639	negative regulation of alpha-beta T cell differentiation
GO:0048074	negative regulation of eye pigmentation
GO:0048469	cell maturation
GO:0048557	embryonic digestive tract morphogenesis
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048666	neuron development
GO:0048745	smooth muscle tissue development
GO:0050679	positive regulation of epithelial cell proliferation
GO:0051216	cartilage development
GO:0060135	maternal process involved in female pregnancy
GO:0060220	camera-type eye photoreceptor cell fate commitment
GO:0060323	head morphogenesis
GO:0061053	somite development
GO:0072498	embryonic skeletal joint development
GO:0090136	epithelial cell-cell adhesion